91AV

邹振兴，男，1987年生，副研究员，硕士生导师，博士/博士后。91AV 药学实验中心副主任，湖南省药学会中药与天然药物委员会青年委员会副主任委员。2009年本科毕业于浙江海洋91AV 食品与药学91AV 医91AV ，2012.6和2016.6年先后获91AV 医学硕士和医学博士学位，2016.11-2018.12在91AV 湘雅医院从事博士后研究，2019.1入职91AV 。

近年来一直从事天然药物化学教学、科研及中药新药研发等相关工作。主要致力于药用蕨类植物（卷柏科、石松科）及内生菌化学成分多样性及生物学功能研究，初步探明了其传统功效与物质基础内在联系，以及生物学功能差异的规律，发现了多个具有显著抗肿瘤、抗炎、神经保护等活性的天然活性先导物。先后在Phytochemistry、Fitoterapia、Chinese Chemical Letters、Frontiers in Pharmacology等国际期刊发表30余篇SCI论文，现为Fitoterapia、NPR、CCL等国际期刊审稿人；先后获得国自青年基金，省自青年基金和中国博士后基金等资助，参与其他国家、省部级及新药研发课题15余项，申请国家发明专利1项。

研究方向：

1. 传统中药、药用植物及其内生真菌天然活性小分子化合物的发现、结构修饰以及生物学功能评价（肿瘤、神经保护、抗炎、抗菌等）

2. 中药新药及健康产品研发

课题组介绍：

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近年主持或参与课题：

1. 国家自然科学基金面上项目，基于herquline A等天然产物生物合成的酚去芳构化生物催化体系的研究和应用，2019/01-2022/12，在研，参加

2. 国家自然科学青年基金，两种卷柏新颖黄酮类成分及BACE1抑制活性研究，2018/01-2020/12，在研，主持

3. 湖南省自然科学青年基金，石上柏新型天然BACE1抑制剂的发现与研究，2018/01-2020/12，在研，主持

4. 中国博士后基金面上项目，基于多靶点作用特征的中药石上柏抗AD药效物质基础研究，2018/01-2018/12，已结题，主持

5. 国家自然科学青年基金，DMATS家族酶催化黄酮定向异戊烯基化的方法研究及其合成应用，2018/01-2020/12，在研，参加

6. 91AV 博士后科研启动项目，基于深绿卷柏新颖黄酮类成分的抗AD新药临床前研究，2016/11-2018/11，已结题，主持

7. 湖南省自然科学基金面上项目，基于COX-2靶点的黑顶卷柏抗肿瘤作用研究，2016/01-2018/12，已结题，参加

8. 海口市应用技术研究与开发经费专项重点项目，海南石上柏新型抗肿瘤活性成分及其作用机制研究，2015/01-2017/12，已结题，参加

9. 国家自然科学基金面上项目，卷柏属植物COX-2抑制剂先导物的发现及抗肺癌作用机制研究，2014/01-2017/12，已结题，参加

代表性文章：

1. Zhenxing Zou, Guishan Tan, Qi Huang, Huihui Sun, Luqiong Huo, Wanqi Zhong, Liyun Zhao, Hongxin Liu*, Haibo Tan*. Brachyanins A-C, pinene-derived meroterpenoids and phloroglucinol derivative fromLeptospermum brachyandrum,Fitoterapia,2018, (130): 184˗189.

2. Zhenxing Zou, Pingsheng Xu, Guogang Zhang, Fei Cheng, Kai Chen, Jing Li, Weixing Zhu, Dongsheng Cao, Kangping Xu^*, Guishan Tan^*, Selagintriflavonoids with BACE1 inhibitory activity from the fernSelaginella doederleinii,Phytochemistry,2017, (134): 114˗121.

3. Zhenxing Zou, Kangping Xu, Pingsheng Xu, Xiaomin Li, Fei Cheng, Jing Li, Xia Yu, Dongsheng Cao, Li Dan, Wei Zeng, Guogang Zhang^*, Guishan Tan^*, Seladoeflavones A-F, six novel flavonoids fromSelaginella doederleinii,Fitoterapia,2017, (116): 66˗71.

4. Zhenxing Zou, Guishan Tan, Guogang Zhang, Xia Yu, Pingsheng Xu^*, Kangping Xu^*, New cytotoxic apigenin derivatives fromSelaginella doederleinii,Chinese Chemical Letters,2017, 28(5): 931˗934.

5. Zhenxing Zou, Pingsheng Xu, Canrong Wu, Weixing Zhu, Gangzhi Zhu, Xiaoai He, Guogang Zhang, Jianzhong Hu, Shao Liu, Wei Zeng, Kangping Xu^*, Guishan Tan^*, Carboxymethyl flavonoids and a chromone with antimicrobial activity fromSelaginella moellendorffiiHieron,Fitoterapia,2016, (111): 124˗129.

6. Zhenxing Zou, Kangping Xu, Fushuang Li, Hui Zou, Minzhen Liu, Qiong Zhang, Kai Yu, Lanfang Zhao, Leihong Tan,Guishan Tan^*, A new pyrrole alkaloid fromSelaginella moellendorfiiHieron,Chinese Chemical Letters,2013, 24(2): 114˗116.

7. Lifei Liu, Huihui Sun, Jianbing Tan, Qi Huang, Fei Cheng, Kangping Xu,Zhenxing Zou^*, Guishan Tan^*, New cytotoxic biflavones fromSelaginella doederleinii,Natural Product Research,2019, online,.

8. Fei Cheng, Kangping Xu, Lifei Liu, Caiping Yao, Pingsheng Xu, Gan Zhou, Dai Li, Xiaomin Li, Kai Chen,Zhenxing Zou^*, Guishan Tan^*, New neolignans fromSelaginella pictaand their protective effect on HT-22 cells,Fitoterapia,2018, (127): 69˗73.

9. Wei Zeng, Caiping Yao, Pingsheng Xu, Guogang Zhang, Zhaoqian Liu, Kangping Xu,Zhenxing Zou^*, Guishan Tan^*, A new neolignan fromSelaginella moellendorffiiHieron,Natural Product Research,2017, 19(31): 2223˗2227.

10. Qi Huang, Jianbing Tan, Xiangchang Zeng, Yaqin Wang,Zhenxing Zou^*, Dongsheng Ouyang^*, Lignans and phenolic constituents fromEucommia ulmoidesOliver,Natural Product Research,2019, ASAP, online, DOI:

11. Qiuzhu Dong,Zhenxing Zou, Xiaohui Jia, Xia Yu, Jing Li, Wenhao Zhou, Huihui Sun, Wei Wu, Guishan Tan, Kangping Xu^*, Cytotoxic polyhydroxy serratene triterpenoids fromLycopodium complanatum,Bioorganic Chemistry,2019, (87): 373˗379.

12. ,,,,,,,,,^*, Selective geranylation of biflavonoids byAspergillus terreusaromatic prenyltransferase (AtaPT),Organic & Biomolecular Chemistry,2019, ASAP, online, DOI: 10.1039/C9OB02296A.

13. Xi Chen, Pingsheng Xu,Zhenxing Zou, Yang Liu, Wenhao Zhou, Qin Ren, Dan Li, Xiaomin Li, Kangping Xu, Guishan Tan^*, Sinensiols B-G, six novel neolignans fromselaginella sinensis,Fitoterapia,2019, (134): 256˗263.

14. Fei Cheng,Zhenxing Zou, Pingsheng Xu, Shuihan Zhang, Yan Zhang, Caiping Yao, Kangping Xu, Guishan Tan^*, Pictalignans D-F, three new neolignan derivatives fromSelaginella picta,Natural Product Research,2019,ASAP, online,.

, Anti-cholinesterase activities of constituents isolated fromLycopodiastrum casuarinoides,Fitoterapia,2019, (139): 104366.

16. Yinhua Deng, Ningning Wang,Zhenxing Zou, Lin Zhang, Kangping Xu, Alex F. Chen, Dongsheng Cao^*, Guishan Tan^*, Multi-target Screening and Experimental Validation of Natural Products fromSelaginellaPlants against Alzheimer’s Disease,Frontiers in Pharmacology,2017, (8): 539.

17. Rui Liu, Hui Zou,Zhenxing Zou, Fei Cheng, Xia Yu, Pingsheng Xu, Xiaomin Li, Dai Li, Kangping Xu^*, Guishan Tan^*, Two new anthraquinone derivatives and one new triarylbenzophenone analog fromSelaginella tamariscina,Natural Product Research,2018, ASAP, online,.

18. Caiping Yao,Zhenxing Zou, Yan Zhang, Jing Li, Fei Cheng, Pingsheng Xu, Gan Zhou, Xiaomin Li, Kangping Xu^*, Guishan Tan^*, New adenine analogues and a pyrrole alkaloid fromSelaginella delicatula,Natural Product Research,2019, 14(33): 1985˗1991.

19. Rui Liu, Hui Zou, Pingsheng Xu,Zhenxing Zou, Jing Li, Fei Cheng, Ruihuan Liu, Gan Zhou, Kangping Xu^*, Guishan Tan^*, Uncinatic acids A-C, three new carboxylated flavonoids fromSelaginella uncinata,Chinese Chemical Letters,2017, 28(7): 1465˗1468.

20. Jing Li, Pingsheng Xu,Zhenxing Zou, Hui Zou, Hongping Long, Leihong Tan, Ruihuan Liu, Yikun Wang, Kangping Xu^*, Guishan Tan^*. Three new compounds from the roots ofJuglans mandshuricaMaxim.Phytochemistry Letters,2017, (20): 40˗44.

联系方式：

通讯地址：湖南省长沙市桐梓坡路172号91AV （孝骞楼614），邮编：410013

Tel：0731-82650395

E-mail：zouzhenxing@csu.edu.cn